Steroids

Preparative chemical methods for aromatization of 19-nor-Δ 4-3-oxosteroids

PN Rao, JW Cessac, HK Kim

Index: Rao, Pemmaraju N.; Cessac, James W.; Kim, Hyun K. Steroids, 1994 , vol. 59, # 11 p. 621 - 627

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Citation Number: 31

Abstract

Abstract Two preparative chemical methods for aromatization of 19-nor-Δ 4-3-oxosteroids are described. The first method consist of an oxidative aromatization of 19-nor-Δ 4-3- oxosteroids with iodine-ceric ammonium nitrate in methanol to give a mixture of 3-methoxy ring-A aromatized derivatives consisting of the desired product, the Δ 9, 11 derivative, the 6- oxo derivative as well as some ring-A iodinated material. Conversion of this material to a ...