Synthesis and Biological Activity of N 4-Methyl-5-azacytidines

NB Hanna, M Masojídková…

Index: Hanna, Naeem B.; Masojidkova, Milena; Piskala, Alois Collection of Czechoslovak Chemical Communications, 1998 , vol. 63, # 5 p. 713 - 722

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Citation Number: 4

Abstract

Abstract Protected N 4-methyl and N 4, N 4-dimethyl derivatives of 5-azacytidine 3 and 4 were prepared by selective aminolysis of benzoylated 4-methoxy-1-(β-D-ribofuranosyl)-1, 3, 5-triazin-2 (1H)-one 5, by glycosylation of silylated N 4-methyl-or N 4, N 4-dimethyl-5- azacytosines 7 and 8 with 2, 3, 5-tri-O-benzoyl-α, β-D-ribofuranosyl chloride (11) or by several modifications of the isocyanate method. By the isocyanate approach, also the α-D ...