Studies on 2 (1H)-quinolinone derivatives as neuroleptic agents. I. Synthesis and biological activities of (4-phenyl-1-piperazinyl)-propoxy-2 (1H)-quinolinone …

K BANNO, T FUJIOKA, T KIKUCHI, Y OSHIRO…

Index: Banno; Fujioka; Kikuchi; Oshiro; Hiyama; Nakagawa Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4377 - 4388

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Citation Number: 32

Abstract

With the aim of developing a novel neuroleptic drug, a series of ω-(4-phenyl-1-piperazinyl)- alkoxy-2 (1H)-quinolinone derivatives have been synthesized and tested for anti- methamphetamine and anti-epinephrine activities. Most of the derivatives were found to possess a potent antimethamphetamine activity in the jumping behavior test on mice treated with 3-(3, 4-dihydroxyphenyl)-L-alanine (L-DOPA) and methamphetamine, or in the ...