Schiff bases of indoline-2, 3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building

T Aboul-Fadl, FAS Bin-Jubair, O Aboul-Wafa

Index: Aboul-Fadl, Tarek; Bin-Jubair, Fayzah A.S.; Aboul-Wafa, Omima European Journal of Medicinal Chemistry, 2010 , vol. 45, # 10 p. 4578 - 4586

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Citation Number: 79

Abstract

Tuberculosis (TB) remains among the world's great public health challenges. Worldwide resurgence of TB is due to two major problems: the AIDS epidemic, which started in the mid- 1980s, and the outbreak of multidrug resistant (MDR) TB. Thus, there is an urgent need for anti-TB drugs with enhanced activity against MDR strains. In recent years, Schiff bases of 1H- indole-2, 3-diones are reported to exhibit anti-TB activity. On the other hand, several ...