Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library

…, JJ Adams, CG Clark, WJ Calhoun, JM Luettgen…

Index: Lam, Patrick Y. S.; Adams, Jessica J.; Clark, Charles G.; Calhoun, W. Jason; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1795 - 1799

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Citation Number: 29

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... In an effort to identify orally bioavailable factor Xa inhibitors, two isoxazolines libraries were prepared to scan for novel P1 ligands. From this work, 4-chloro-3-aniline was identified as a novel and potent benzamidine mimic. ... In an effort to identify orally bioavailable factor Xa inhibitors, two ...