Synthesis, Biological Evaluation, and Structure–activity Relationship of Clonazepam, Meclonazepam, and 1, 4??Benzodiazepine Compounds with Schistosomicidal …

…, MA Alves, DN Do Amaral, JPB Thibaut…

Index: Menezes, Carla M.S.; Rivera, Gildardo; Alves, Marina A.; Do Amaral, Daniel N.; Thibaut, Jean Pierre B.; Noel, Francois; Barreiro, Eliezer J.; Lima, Lidia M. Chemical Biology and Drug Design, 2012 , vol. 79, # 6 p. 943 - 949

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Citation Number: 13

Abstract

The inherent morbidity and mortality caused by schistosomiasis is a serious public health problem in developing countries. Praziquantel is the only drug in therapeutic use, leading to a permanent risk of parasite resistance. In search for new schistosomicidal drugs, meclonazepam, the 3-methyl-derivative of clonazepam, is still considered an interesting lead-candidate because it has a proven schistosomicidal effect in humans but adverse ...