Synthesis and biological activity of zoapatanol analogs

MC Wani, BR Vishnuvajjala, WE Swain Jr…

Index: Wani, Mansukh C.; Vishnuvajjala, B. Rao; Swain, William E.; Rector, Douglas H.; Cook, Clarence E.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 426 - 430

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Citation Number: 8

Abstract

Dioxane analogues of the biologically active 3, 6-oxido derivative (111) of zoapatanol (I) having substituents at the C-2 and C-5 positions, but lacking the ethano bridge, were evaluated for luteolytic and postcoital antifertility activity in the guinea pig. Whether injected sc for 3 days (days 12-14 or 22-24 postmating) or administered ip as a single dose on day 22 postmating, none of the four analogues was active at the doses tested.

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[Fujisawa, Tamotsu; Sato, Toshio; Kawara, Tatsuo; Noda, Atsunari Tetrahedron Letters, 1982 , vol. 23, # 31 p. 3193 - 3194]