Design of a novel class of biphenyl CETP inhibitors

…, LB Peterson, MS Anderson, SS Eveland, Q Guo…

Index: Lu, Zhijian; Napolitano, Joann B.; Theberge, Ashleigh; Ali, Amjad; Hammond, Milton L.; Tan, Eugene; Tong, Xinchun; Xu, Suoyu S.; Latham, Melanie J.; Peterson, Laurence B.; Anderson, Matt S.; Eveland, Suzanne S.; Guo, Qiu; Hyland, Sheryl A.; Milot, Denise P.; Chen, Ying; Sparrow, Carl P.; Wright, Samuel D.; Sinclair, Peter J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7469 - 7472

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Citation Number: 11

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model. ... A new class of CETP inhibitors was designed and prepared. These ...