Chemoenzymatic synthesis of the two enantiomers of 7-azatryptophan

…, V Rolland-Fulcrand, ML Roumestant, P Viallefont…

Index: Lecointe; Rolland-Fulcrand; Roumestant; Viallefont; Martinez Tetrahedron Asymmetry, 1998 , vol. 9, # 10 p. 1753 - 1758

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Citation Number: 13

Abstract

7-Azatryptophan is an unnatural α-amino acid with a very potent fluorescent activity. It is used as a vehicle for probing the structure and dynamics of proteins and peptides. Diastereoselective alkylation, diastereoselective protonation and enzymatic resolution have been tested for preparing enantiomerically pure 7-azatryptophan.