Journal of medicinal chemistry

… the search for new anticancer drugs. 17. Linear and cyclic polyether analogs of N, N: N', N': N", N"-tri-1, 2-ethanediylphosphoric triamide and N, N: N', N': N", N"-tri-1, 2- …

G Sosnovsky, J Lukszo, NU Rao

Index: Sosnovsky, George; Lukszo, Jan; Rao, N. Uma Maheswara Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1250 - 1256

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Citation Number: 8

Abstract

N, Nf” JV ': N ''JV''-tri-1, 2-ethanediylphosphorothioic triamide (thio-TEPA) are synthesized and evaluated for their antineoplastic activity against the murine lymphocytic leukemia P388. All compounds, except for 7 4 were active ranging from 42% to 287% increase in life span