Search for antialcoholic agents in the series of amides of substituted pyrazole-4-carboxylic and pyrazole-4-acetic acids

VA Zagorevskii, NV Vlasova, DA Zykov…

Index: Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971

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Abstract

Intensified activity of ethanol-oxidizing enzymic systems (EOES) leads to considerable disturbance of metabolic processes, by a suddenly increased synthesis of acetaldehyde [9,! 0, 14, 15]. The activation of these systems in some cases predicates an attraction to alcohol, and is involved in the mechanism of obtaining a state of abstinence [3]. Based on this, a hypothesis was advanced of the possibility of using a pharmacological inhibiting action at ...

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