Abstract (3-Hydroxy-3-methylbutyn-1-yl) cycloalkan-1-ols were prepared by the action of (2- lithiooxy-2-methylbutyn-3-yl) lithium on cyclopentanone, cyclohexanone, cycloheptanone, and cyclododecanone. The products react with acetonitrile under Ritter reaction conditions. Therewith, in the presence of 8 g-equiv of sulfuric acid, a 2: 1 mixture of 1-acetylamino-1-(2- acetylamino-2-methylbutyn-3-yl) cycloalkanes and 1-acetylamino-1-(3-acetylamino-3- ...
