Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists

…, L Noronha-Blob, A Kirkien-Rzeszotarski

Index: Rzeszotarski, W. Janusz; McPherson, Daniel W.; Ferkany, John W.; Kinnier, William J.; Noronha-Blob, Lalita; Kirkien-Rzeszotarski, Alicja Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1463 - 1466

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Citation Number: 35

Abstract

All of the optical isomers of the muscarinic antagonists 3-(1-azabicyclo [2.2. 2] octyl) a- hydroxy-a, a-diphenylacetate (3-quinuclidinyl benzilate, QNB, l), 3-(l-azabicyclo [2.2. 2] octyl) xanthene-9-carboxylate (3-quinuclidinyl xanthene-9-carboxylate, QNX, 2), and 3-(l- azabicyclo [2.2. 2] ocytl) a-hydroxy-a-phenylpropionate (3-quinuclidinyl atrolactate, QNA, 3) were prepared and studied in binding and functional assays. In all instances the esters of ( ...