Low molecular weight lignin suppresses activation of NF-κB and HIV-1 promoter

S Mitsuhashi, T Kishimoto, Y Uraki, T Okamoto…

Index: Mitsuhashi, Shinya; Kishimoto, Takao; Uraki, Yasumitsu; Okamoto, Takashi; Ubukata, Makoto Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2645 - 2650

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Citation Number: 22

Abstract

Human immunodeficiency virus type 1 (HIV-1) is a cytopathic retrovirus and the primary etiological agent of acquired immunodeficiency syndrome (AIDS) and related disorders. In cells chronically infected with HIV-1, nuclear factor-κB (NF-κB) activation by external stimuli such as tumor necrosis factor α (TNFα) augments replication of HIV-1. NF-κB involves in many diseases such as inflammation, cancer, and Crohn's disease. In this paper, we ...