Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis

GL Newton, N Buchmeier, JJ La Clair…

Index: Newton, Gerald L.; Buchmeier, Nancy; La Clair, James J.; Fahey, Robert C. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 13 p. 3956 - 3964

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Citation Number: 19

Abstract

Abstract The mycothiol biosynthesis enzyme MshC catalyzes the ligation of cysteine with the pseudodisaccharide GlcN-Ins and has been identified as an essential enzyme in Mycobacterium tuberculosis. We now report on the development of NTF1836 as a micromolar inhibitor of MshC. Using commercial libraries, we conducted preliminary structure–activity relationship (SAR) studies on NTF1836. Based on this data, NTF1836 ...