Copper??Catalyzed Amidation of Acids Using Formamides as the Amine Source

YX Xie, RJ Song, XH Yang, JN Xiang…

Index: Xie, Ye-Xiang; Song, Ren-Jie; Yang, Xu-Heng; Xiang, Jian-Nan; Li, Jin-Heng European Journal of Organic Chemistry, 2013 , # 25 p. 5737 - 5742

Full Text: HTML

Citation Number: 14

Abstract

Abstract Copper-catalyzed amidation of acids with formamides or acetamide for the selective synthesis of amides with the aid of 1, 4-diazabicyclo [2.2. 2] octane as the ligand and tert- butyl hydroperoxide as the oxidant is presented. This method is highly compatible with a wide range of acids, including alkyl acids, aryl acids, α, β-unsaturated acids, and amino acids.