Tetrahedron

Synthesis of dihydropyrazolo [3′, 4′: 3, 4] pyrrolo [1, 2-a] indoles and spiro-[3H-indole-3, 3′-[Δ 2-1, 2, 4]-triazolin]-2-ones via intra and intermolecular 1, 3-dipolar …

D Prajapati, S Gadhwal

Index: Prajapati, Dipak; Gadhwal, Sunil Tetrahedron, 2004 , vol. 60, # 22 p. 4909 - 4913

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Citation Number: 14

Abstract

The potent antitumour antibiotic mitomycins 1 have attracted a great deal of interest and a variety of molecular manipulations have been reported without loss of any significant biological activities. 2 Indeed mitomycin C is a clinically useful chemotherapeutic agent for the treatment of various tumors. Although numerous C 1 -fused furan, thiophene and pyridine annelated mitomycins are reported, they have their limitations due to the fact that these heterocycles are not ...