Synlett

One-pot synthesis of substituted pyridines via the Vilsmeier-Haack reaction of acyclic ketene-S, S-acetals

S Sun, Y Liu, Q Liu, Y Zhao, D Dong

Index: Sun, Shaoguang; Liu, Yingchun; Liu, Qun; Zhao, Yulong; Dong, Dewen Synlett, 2004 , # 10 p. 1731 - 1734

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Citation Number: 22

Abstract

Functionalized pyridines and their benzo/hetero-fused analogues represent an important class of organic molecules for their presence in numerous natural products along with useful bio-, physio- and pharmacological activities. [1] [2] The synthesis of the pyridine derivatives can principally be realized either by modification of the pre-constructed pyridine nucleus or through the construction of the pyridine ring from appropriately substituted open chain precursor, which have been ...