New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy) quinoline …

…, M Dennis, E Fisher, JS Major, BB Masek…

Index: Bradbury; Allott; Dennis; Fisher; Major; Masek; Oldham; Pearce; Rankine; Revill; Roberts; Russell Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4027 - 4038

Full Text: HTML

Citation Number: 58

Abstract

A novel series of nonpeptidic angiotensin I1 (AII) receptor antagonists is reported, derived from linkage of the biphenylcarboxylic acid or biphenylyltetrazole moiety found in previously described antagonists via a methyleneoxy chain to the 4-position of a 2-alkyl quinoline. When evaluated in an in vitro binding assay using a guinea pig adrenal membrane preparation, compounds in this series generally gave IC50 values in the range 0.01-1 pM. ...