2, N 6, and 5'-substituted adenosine derivatives were synthesized via alkylation of 2- oxypurine nucleosides leading to 2-arylalkylether derivatives. 2-(3-(Indolyl) ethyloxy) adenosine 17 was examined in both binding and cAMP assays and found to be a potent agonist of the human A2BAR. Simplification, altered connectivity, and mimicking of the indole ring of 17 failed to maintain A2BAR potency. Introduction of N 6-ethyl or N 6- ...
