Abstract: Novel congeners of the antiretroviral compound 2', 3'-dideoxyadenosine (ddA) have been synthesized through metal-mediated and photochemical conversions as the key steps. These compounds are inherently more stable than ddA with respect to both glycosidic bond cleavage and deamination by adenosine deaminase.
![6-amino-9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]purine-2-carbonitrile Structure](https://image.chemsrc.com/caspic/348/122970-25-6.png)