Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy) methyl] pyrazolo [3, 4-d] pyrimidine analogs of sangivamycin and toyocamycin

…, LA Coleman, JC Drach, LB Townsend

Index: Saxena, Naveen K.; Coleman, Lisa A.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1980 - 1983

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Citation Number: 18

Abstract

Acyclonucleosides are an important class of compounds acyclic nucleosides, acyclovir2 and ganciclovir3+(DHPG) have been key compounds in the search for better drugs. The specificity of these compounds against herpes simplex virus types 1 and 2 (HSV-1, HSV-2) is a consequence of differential substrate specificity between cellular and viral kinases and of biochemical selectivity at the level of DNA polymerases. 6 Both of these compounds ...