Helvetica Chimica Acta

RNA cleavage catalyzed by amphoteric bis (acyl) guanidinium derivatives

MW Göbel, CD Roussev, U Scheffer

Index: Goebel, Michael W.; Roussev, Christo D.; Scheffer, Ute Helvetica Chimica Acta, 2014 , vol. 97, # 2 p. 215 - 227

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Citation Number: 3

Abstract

Abstract Described herein are two series (twelve compounds each) of very closely related guanidinium-based receptors and their ability to catalyze hydrolytic cleavage of a unique RNA substrate–oligo-dT flanked trans-Activation Responsive region of the HIV-1 mRNA, TAR RNA. The significant difference in activities of otherwise very similar compounds is discussed, and direct and indirect evidences supporting our interpretation are presented. ...