Synthesis and biological evaluation of substituted benzo [h] cinnolinones and 3H-benzo [6, 7] cyclohepta [1, 2-c] pyridazinones: higher homologs of the …

…, M Germini, P Cazzulani, E Cavalletti

Index: Cignarella; Barlocco; Pinna; Loriga; Curzu; Tofanetti; Germini; Cazzulani; Cavalletti Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2277 - 2282

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Citation Number: 48

Abstract

Several substituted benzo [h] cinnolinones 3 and 3H-benzo [6, 7] cyclohepta [1, 2-c] pyridazinones 4, which were designed as less rigid congeners of 5H-indeno [1, 2-c] pyridazinones 2, were synthesized and tested as antihypertensive, inotropic, antithrombotic, antiinflammatory, and antiulcer agents. While the seven-membered ring derivatives displayed only antithrombotic properties, which were comparable to that of acetylsalicylic ...