Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (−)-epicatechin gallate

JC Anderson, RA McCarthy, S Paulin…

Index: Anderson, James C.; McCarthy, Robert A.; Paulin, Sarah; Taylor, Peter W. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 6996 - 7000

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Citation Number: 17

Abstract

We examined the impact of gradual removal of hydroxyl groups from the A-and B-rings of (−)- epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcusaureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin ...