Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins

Y Tanaka, K Aikawa, G Nishida, M Homma…

Index: Hickey, Deirdre M. B.; Moody, Christopher J.; Rees, Charles W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1119 - 1122

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Citation Number: 42

Abstract

... Journal of Medicinal ... J. Med. ... The discovery of compound 1 (ABT-737, Figure 1)(12-16) and the closely related compound 2 (ABT-263, Figure 1) was a notable success reported by Abbott Laboratories.(17-22) These compounds inhibit Bcl-xL, Bcl-2, and Bcl-w with high affinities ...

~56%

Imidazopyridine CB2 agonists: optimization of CB2/CB1 select...

[Trotter, B. Wesley; Nanda, Kausik K.; Burgey, Christopher S.; Potteiger, Craig M.; Deng, James Z.; Green, Ahren I.; Hartnett, John C.; Kett, Nathan R.; Wu, Zhicai; Henze, Darrell A.; Penna, Kimberly Della; Desai, Reshma; Leitl, Michael D.; Lemaire, Wei; White, Rebecca B.; Yeh, Suzie; Urban, Mark O.; Kane, Stefanie A.; Hartman, George D.; Bilodeau, Mark T. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2354 - 2358]

Microwave-assisted organic synthesis of 3-substituted-imidaz...

[Arvapalli, Venkata Satyanarayana; Chen, Guangwu; Kosarev, Sergey; Tan, Meifen Evonne; Xie, Dejian; Yet, Larry Tetrahedron Letters, 2010 , vol. 51, # 2 p. 284 - 286]