Synthesis and Cu1+ Assisted radiosynthesis of 2??radioiodo phloretinic acid, a potential glut tracer

…, R Boumon, P Steegmans

Index: Mertens, J.; Boumon, R.; Steegmans, P. Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S951 - S953

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Abstract

Abstract 2-Bromo-phloretinic acid (2-Br-PLA): 2-bromo-4-(3-oxo-3 (2, 4, 6-trihydroxyphenyl) propyl) benzoic acid, the precursor molecule for the radiosynthesis of 2-radioiodophloretinic acid (2-* I-PLA): 2-radioiodo-4-(3-oxo-3 (2, 4, 6-trihydroxyphenyl)-propyl) benzoic acid, was prepared by a twelve step synthesis starting from hydrocinnamic acid. The radiosynthesis was carried out by applying the Cu (I)-assisted nucleophilic non-isotopic exchange ...

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