Accelerating Palladium??Catalyzed C F Bond Formation: Use of a Microflow Packed??Bed Reactor

…, TJ Maimone, SL Buchwald

Index: Noel, Timothy; Maimone, Thomas J.; Buchwald, Stephen L. Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8900 - 8903

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Citation Number: 69

Abstract

The aryl fluoride motif is a mainstay in a variety of disciplines, most notably pharmaceuticals, agrochemicals, and in positron emission tomography (PET). A large number of clinically approved pharmaceuticals contain this substituent due to its importance in tailoring the properties of organic molecules.[1] While numerous methods have been developed to construct aromatic CÀF bonds, most, if not all, suffer from at least one drawback with ...