Studies on Condensed Pyrimidine Systems. VI. Some 2-Aminothiazolo [4, 5-d]-pyrimidines1, 2

A Maggiolo, GH Hitchings

Index: Maggiolo; Hitchings Journal of the American Chemical Society, 1951 , vol. 73, p. 4226

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Citation Number: 15

Abstract

Thiocyanation in the 5-position occurs readily with pyrimidines bearing at least two hydroxyl or amino groups in positions 2, 4 and 6. An alternate synthesis of thiazold 4, 5-d] pyrimidines bearing non-functional substituents in the 2-and 4-position also was developed. In the latter method a 4-thiocyanopyrimidine is formed by the reaction of a 4-ehloropyrimidine with potassium thiocyanate and after isomerization is eventually converted to a ...