e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

RG Schmidt, EK Bayburt, SP Latshaw…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 5 p. 1338 - 1341

Full Text: HTML

Citation Number: 35

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... 5, 6 and 7 In the meantime the search for TRPV1 antagonists with suitable ADME, pharmacological, physico-chemical and toxicological profile continues. ...

1-(tert-Butyl)-2-(prop-2-yn-1-yloxy)benzene Structure

1-(tert-Butyl)-...

~%

8-(TERT-BUTYL)CHROMAN-4-ONE Structure

8-(TERT-BUTYL)C...

2-tert-Butylphenol Structure

2-tert-Butylphenol

~%

8-(TERT-BUTYL)CHROMAN-4-ONE Structure

8-(TERT-BUTYL)C...

N/A Structure

~%

(S)-7-(TRIFLUOROMETHYL)CHROMAN-4-AMINE Structure

(S)-7-(TRIFLUOR...

7-(trifluoromethyl)chroman-4-one Structure

7-(trifluoromet...

~%

(S)-7-(TRIFLUOROMETHYL)CHROMAN-4-AMINE Structure

(S)-7-(TRIFLUOR...

N/A Structure

~%

(R)-7-(TRIFLUOROMETHYL)CHROMAN-4-AMINE Structure

(R)-7-(TRIFLUOR...

7-(trifluoromethyl)chroman-4-one Structure

7-(trifluoromet...

~%

(R)-7-(TRIFLUOROMETHYL)CHROMAN-4-AMINE Structure

(R)-7-(TRIFLUOR...

1-prop-2-ynoxy-2-(trifluoromethyl)benzene Structure

1-prop-2-ynoxy-...

~%

8-(trifluoromethyl)chroman-4-one Structure

8-(trifluoromet...

2-(Trifluoromethyl)phenol Structure

2-(Trifluoromet...

~%

8-(trifluoromethyl)chroman-4-one Structure

8-(trifluoromet...

1-bromoprop-1-yne Structure

1-bromoprop-1-yne

Phenol Structure

~%

phenyl 2-propynyl ether Structure

phenyl 2-propyn...

6-methylchroman-4-one Structure

6-methylchroman...

~%

6-methylchroman-4-amine Structure

6-methylchroman...