Synthesis of some 3, 7??disubstituted quino [3, 2??c][1, 8] naphthyridines

A Da Settimo, G Biagi, G Primofiore…

Index: Da Settimo; Biagi; Primofiore; et al. Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1225 - 1229

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Citation Number: 19

Abstract

Abstract The preparation of some 3, 7-disubstituted-5, 6-dihydroquino [3, 2-c][1, 8] naphthyridines (6) by the condensation of 7-substituted-2, 3-dihydro-1, 8-naphthyridin-4- (1H) ones (5) with o-aminoacetophenone or o-aminobenzophenone is described. All the 5, 6-dihydroderivatives 6 were transformed into the fully aromatic compounds 7 by heating with nitrobenzene. Only a few quino [3, 2-c][1, 8] naphthyridines were previously described.