Antibacterial activity of substituted 5-methylbenzo [c] phenanthridinium derivatives

…, C Kelley, M Kaul, DS Pilch, EJ LaVoie

Index: Parhi, Ajit; Kelley, Cody; Kaul, Malvika; Pilch, Daniel S.; Lavoie, Edmond J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7080 - 7083

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Citation Number: 24

Abstract

Antibiotic resistance has prompted efforts to discover antibiotics with novel mechanisms of action. FtsZ is an essential protein for bacterial cell division, and has been viewed as an attractive target for the development of new antibiotics. Sanguinarine is a benzophenanthridine alkaloid that prevents cytokinesis in bacteria by inhibiting FtsZ self- assembly. In this study, a series of 5-methylbenzo [c] phenanthridinium derivatives were ...