Convenient method of synthesizing 3-ethoxycarbonyl indoles

…, C Brennan, Q Wang, MM Hossain

Index: Dudley, Matthew E.; Morshed, Monzur; Brennan, Courtney L.; Islam, M. Shahidul; Ahmad, M. Syarhabil; Atuu, Mary-Rose; Branstetter, Bryan; Hossain, M. Mahmun Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7599 - 7608

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Citation Number: 25

Abstract

We have developed a convenient two-step procedure for the synthesis of 3-ethoxycarbonyl indoles from commercially available materials. The two-step procedure involves the synthesis of 2-aryl-3-hydroxypropenoic acid ester, followed by a catalytic reduction. This method is efficient, simple, and selective.

~19%

~23%

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