Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis

R Junek, M Kverka, A Jandera, V Panajotová…

Index: Junek, Richard; Kverka, Miloslav; Jandera, Antonin; Panajotova, Vladimira; Satinsky, Dalibor; Machacek, Milos; Kuchar, Miroslav European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 332 - 344

Full Text: HTML

Citation Number: 9

Abstract

A series of arylalkanoic acid derivatives bearing methyl (phenethyl) amino groups were prepared and their inhibition of LTB4 biosynthesis was evaluated. Regression analysis showed the slightly different parabolic dependences of this activity on lipophilicity of α- methyl and α-unsubstituted alkanoic acid derivatives. The relationship derived for α- unsubstituted alkanoic acids was extended by previously prepared group of similar ...