Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements

…, R Kurukulasuriya, D Madar, JR Patel, S Fung…

Index: Yeh, Vince S.C.; Kurukulasuriya, Ravi; Madar, David; Patel, Jyoti R.; Fung, Steven; Monzon, Katina; Chiou, William; Wang, Jiahong; Jacobson, Peer; Sham, Hing L.; Link Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5408 - 5413

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Citation Number: 39

Abstract

A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and 11β-HSD2 selectivity.