Angewandte Chemie International Edition

Enantio??and Diastereoselective Assembly of Tetrahydrofuran and Tetrahydropyran Skeletons with All??Carbon??Substituted Quaternary Stereocenters

Z Chen, J Sun

Index: Wang, Zhaobin; Chen, Zhilong; Sun, Jianwei Angewandte Chemie - International Edition, 2013 , vol. 52, # 26 p. 6685 - 6688 Angew. Chem., 2013 , vol. 125, # 26 p. 6817 - 6820,4

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Citation Number: 33

Abstract

Tetrahydrofuran (THF) and tetrahydropyran (THP) as well as their analogues in higher oxidation states are important structural units found in natural products and bioactive unnatural molecules.[1] Among them, many have all-carbonsubstituted quaternary stereocenters in the 3-/4-(THF) and 3-/5-(THP) positions, such as the highly neurotrophic compounds jiadifenin and tricholomalide A, the anticancer compound maoecrystal V, and ...