A prior communication'described preparation and biological effects of a series of N- methoxylated analogs 1-4 of certain cholinergic agents related to acetylcholine. These methoxyammonium compounds, with one exception, exhibited a low order of cholinergic activity. The unexpected and unexplained dramatically high muscarinic activity of 4, the N- methoxy congener of Bethanechol, suggested further investigation of simple cholinergic ...
