Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives

…, S Rodríguez-Morales, A Hernández-Campos…

Index: Valdez-Padilla, David; Rodriguez-Morales, Sergio; Hernandez-Campos, Alicia; Hernandez-Luis, Francisco; Yepez-Mulia, Lilian; Tapia-Contreras, Amparo; Castillo, Rafael Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 4 p. 1724 - 1730

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Citation Number: 41

Abstract

In this paper are reported the synthesis and antiprotozoal activity in vitro of 24 1- methylbenzimidazole derivatives (13–36) substituted at position 2 with aminocarbonyl, N- methylaminocarbonyl, N, N-dimethylaminocarbonyl, ethoxycarbonyl, 1-hydroxyethyl and acetyl groups, some of them with chlorine atoms at the benzenoid ring. Compounds 13–36 were more active than metronidazole, the choice drug against Giardia intestinalis and ...