Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation

…, M Norberg, E Sausville, GV Woude, D Wenkert

Index: Shen, Yuehai; Xie, Qian; Norberg, Monica; Sausville, Edward; Vande Woude, George; Wenkert, David Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4960 - 4971

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Citation Number: 17

Abstract

Ansamycins, including geldanamycin and the derivative 17-allylamino-17- demethoxygeldanamycin, and radicicol are known for their ability to tightly bind to the ATP- binding site of the amino-terminal domain region of heat shock protein 90. We have found that geldanamycin and some of its derivatives can inhibit hepatocyte growth factor/scatter factor-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen ...