e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl) ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing …
BD Roth, CJ Blankley, AW Chucholowski…
Index: Roth, B. D.; Blankley, C. J.; Chucholowski, A. W.; Ferguson, E.; Hoefle, M. L.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 357 - 366
19 (a) LiAlH,, ether-dichloromethane, reflux;(b) Et3SiH, TFA-CHpC12, 0 OC;(c) p-TSA, acetone-water. lactone stereoisomers 3 by (1) Weiler dianion condensation with ethyl acetoacetate,(2) stereoselective reduction to the syn-l, &diol with tributylborane and sodium borohydride,(3) base hydrolysis, and (4) lactonization by refluxing in toluene with azeotropic removal of water (Scheme I). The requisite propionaldehydes 2 were prepared by several ...
amino]-4-fluorobenzeneacetic acid,ethyl ester Structure](https://image.chemsrc.com/caspic/225/110862-43-6.png)
![1-[2-(1,3-dioxolan-2-yl)ethyl]-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide Structure](https://image.chemsrc.com/caspic/149/110862-45-8.png)
amino]-4-fluorobenzeneacetic acid Structure](https://image.chemsrc.com/caspic/187/110862-44-7.png)
