Soft Matter

Construction of a smart glutathione peroxidase mimic with temperature responsive activity based on block copolymer

Y Yin, L Wang, H Jin, C Lv, S Yu, X Huang, Q Luo, J Xu…

Index: Yin, Yanzhen; Wang, Liang; Jin, Haiyan; Lv, Chunyan; Yu, Shuangjiang; Huang, Xin; Luo, Quan; Xu, Jiayun; Liu, Junqiu Soft Matter, 2011 , vol. 7, # 6 p. 2521 - 2529

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Citation Number: 22

Abstract

To construct a smart artificial antioxidative enzyme on a nano-scaffold, a novel method for designing glutathione peroxidase (GPx) active sites on block copolymer vesicles was developed by simple blending predesigned temperature-sensitive block copolymers with the main catalytic units of GPx. A series of functional block copolymers, poly (N- isopropylacrylamide)-b-polyacrylamides loaded with recognition and catalytic sites, were ...