7-Azabicyclo [2.2. 1] heptane as a structural motif to block mutagenicity of nitrosamines

…, K Inami, T Yanagimoto, F Karaki, Y Kabasawa…

Index: Ohwada, Tomohiko; Ishikawa, Satoko; Mine, Yusuke; Inami, Keiko; Yanagimoto, Takahiro; Karaki, Fumika; Kabasawa, Yoji; Otani, Yuko; Mochizuki, Masataka Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2726 - 2741

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Citation Number: 10

Abstract

Nitrosamines are potent carcinogens and toxicants in the rat and potential genotoxins in humans. They are metabolically activated by hydroxylation at an α-carbon atom with respect to the nitrosoamino group, catalyzed by cytochrome P450. However, there has been little systematic investigation of the structure–mutagenic activity relationship of N-nitrosamines. Herein, we evaluated the mutagenicity of a series of 7-azabicyclo [2.2. 1] heptane N- ...