Archiv der Pharmazie

Synthesis and Evaluation of Benzophenone O??Glycosides as α??Glucosidase Inhibitors

Q Liu, T Guo, W Li, D Li, Z Feng

Index: Liu, Qingchao; Guo, Tiantian; Li, Wenhong; Li, Dong; Feng, Zili Archiv der Pharmazie, 2012 , vol. 345, # 10 p. 771 - 783

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Citation Number: 7

Abstract

Abstract The first total synthesis of benzophenone O-glycosides (iriflophenone 2-O-α-L- rhamnopyranoside: 1 and aquilarisinin: 2) isolated from the leaves of Aquilaria sinensis and related new derivatives (3–12) was accomplished through suitable protecting group manipulations and glycosylation starting from commercially available L-rhamnose, D- glucose, D-galactose, D-mannose, D-xylose, and 1, 3, 5-trihydroxybenzene. All ...