Tetrahedron letters

Microwave assisted synthesis of 5-hydroxy-5-trichloromethyl-4, 5-dihydroisoxazoles

…, AP Sinhorin, RF Blanco, R Peres, HG Bonacorso…

Index: Martins, Marcos A.P; Beck, Paulo; Cunico, Wilson; Pereira, Claudio M.P; Sinhorin, Adilson P; Blanco, Rogerio F; Peres, Rodrigo; Bonacorso, Helio G; Zanatta, Nilo Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7005 - 7008

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Citation Number: 38

Abstract

A series of 13 5-hydroxy-5-trichloromethyl-4, 5-dihydroisoxazoles have been synthesized in 78–96% yield by environmentally benign microwave induced techniques involving the cyclocondensation of 4-alkoxy-1, 1, 1-trichloro-3-alken-2-ones [CCl3C (O) C (R2)= C (R1) OR, where R2= H, alkyl; R1= H, alkyl, aryl and R= H, alkyl] with hydroxylamine using toluene as solvent. The advantages obtained by the use of microwave irradiation in relation to a ...