Tetrahedron letters

Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes

J Casas, H Sundén, A Córdova

Index: Casas, Jesus; Sunden, Henrik; Cordova, Armando Tetrahedron Letters, 2004 , vol. 45, # 32 p. 6117 - 6119

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Citation Number: 105

Abstract

Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes with formaldehyde has been developed, which furnished the corresponding α- hydroxymethylated adducts with high chemo-and enantioselectivity. The reaction is catalyzed by proline derivatives and is a simple method for the enantioselective synthesis of α-hydroxymethylated ketones and aldehydes, and C-2 symmetric diols.