1, 3-Dipolar cycloaddition chemistry for the preparation of novel indolizinone-based compounds

EM Mmutlane, JM Harris, A Padwa

Index: Mmutlane, Edwin M.; Harris, Joel M.; Padwa, Albert Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 8055 - 8063

Full Text: HTML

Citation Number: 27

Abstract

Starting from methyl 5-oxo-6-trifluoromethanesulfonyloxy-1, 2, 3, 5-tetrahydroindolizine-8- carboxylate, obtained by a Rh (II)-catalyzed 1, 3-dipolar cycloaddition reaction of 1-(2- benzenesulfonyl-2-diazoacetyl) pyrrolidin-2-one and methyl acrylate, several indolo-and furano-fused indolizinones were efficiently prepared. In the first case, a palladium-mediated CN coupling of the triflate with a variety of substituted anilines provided the desired methyl ...