Cyclopenta [b] thiophene-alkyloxazolines: new nitrogen–sulfur hybrid ligands and their use in asymmetric palladium-catalyzed allylic alkylation

…, L Giordano, M Fochi, M Comes-Franchini…

Index: Bonini, Bianca-Flavia; Giordano, Laurent; Fochi, Mariafrancesca; Comes-Franchini, Mauro; Bernardi, Luca; Capito, Elena; Ricci, Alfredo Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1043 - 1051

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Citation Number: 13

Abstract

New chiral nitrogen and sulfur containing hybrid ligands have been prepared and fully characterized. Their structure includes cyclopenta [b] tiophene and oxazoline moieties as sources of chirality. Their catalytic activity has been tested successfully in the Pd-allylic alkylation leading to enantioselectivities of up to 74% ee.