Excessive calpain activations contribute to serious cellular damage and have been found in many pathological conditions. Novel chromone carboxamides derived from ketoamides were prepared and evaluated for μ-calpain inhibition. Among synthesized, compound 2i was the most potent calpain inhibitor with an IC50 value of 0.24±0.11 μM comparable to the activity of peptide aldehyde calpain inhibitor MDL 28,170. Furthermore, compound 2i ...
![1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one Structure](https://image.chemsrc.com/caspic/140/20632-12-6.png)