A stabilized dehydrosecodine analogue bearing carbomethoxy groups in the 3-and 5- positions of the di-hydropyridine moiety has been prepared and its chemistry studied. Two novel procedures have been developed for this synthesis:(1) the Lewis acid assisted cleavage of an activated indole ether with trimethylsilyl cyanide to form a cyano alcohol and (2) the oxidation of 2-(a-substituted ethy1) indoles with tert-butyl hypochlorite to form the ...
[Gray, Nancy M.; Dappen, Michael S.; Cheng, Brian K.; Cordi, Alexis A.; Biesterfeldt, John P.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1283 - 1292]
![Pyrano[3,4-b]indol-1(3H)-one, 4,9-dihydro- Structure](https://image.chemsrc.com/caspic/425/6250-88-0.png)
