Synthesis of optically pure. alpha.-alkylated. alpha.-amino acids and a single-step method for enantiomeric excess determination

…, J Bolster, RM Kellogg, J Kamphuis…

Index: Kruizinga, Wim H.; Bolster, John; Kellogg, Richard M.; Kamphuis, Johan; Boesten, Wilhelmus H. J.; et al. Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1826 - 1827 Title/Abstract Full Text View citing articles Show Details Kaptein; Boesten; Broxterman; Peters; Schoemaker; Kamphuis Tetrahedron Asymmetry, 1993 , vol. 4, # 6 p. 1113 - 1116

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Citation Number: 131

Abstract

Summary: A method for the enzymatic resolution of the amides of some racemic a-alkylated amino acids is described as well as a method involving derivatization with (S)-2-~ hloropropionyl chloride followed by lH NMR analysis to establish the enantiomeric excesses of the free amino acids.